ENGINEERING OF CYTOLETHAL DISTENDING TOXIN B BY ITS REDUCING IMMUNOGENICITY AND MAINTAINING STABILITY AS A NEW DRUG CANDIDATE FOR TUMOR THERAPY; AN IN SILICO STUDY

The cytolethal distending toxin (CDT), Haemophilus ducreyi, is one of the bacterial toxins that have recently been considered for targeted therapies, especially in cancer therapies.CDT is an A-B2 exotoxin.Its catalytic subunit (CdtB) is capable of inducing DNA double strand breaks, cell cycle arrest and apoptosis in host eukaryotic cells.The sequen

The asymmetric unit of the title compound, C25H29N3O, comprises 3 Piece Outdoor Modular Seating two crystallographically independent molecules.The dihedral angles between the benzene rings in the two molecules are 59.7 (2) and 61.27 (18)°.The cyclohexene rings Coffee Grinder adopt sofa and half-chair conformations.In th

IgE-mediated allergy to birch pollen affects more than 100 million patients world-wide.Bet v 1, a 17 kDa protein is the major allergen in birch pollen responsible for allergic rhinoconjunctivitis and asthma in birch pollen allergic patients.Allergen-specific immunotherapy (AIT) based on therapeutic administration of Bet v 1-containing vaccines is a

Objective To identify the variables of videofluoroscopic swallowing study (VFSS) that are useful for predicting the risk of aspiration pneumonia in elderly patients with dysphagia.Methods A total of 251 patients (aged 65 years or more) were included and divided into a pneumonia group (n=133) and a ORG DRIED CRANBERIES non-pneumonia group (n=118).Th

Chilling injury (CI) is a physiological disorder that is occasionally Beauty reported on fresh citrus shipments from Florida.It is most often characterized by areas of the peel that collapse and darken to form pits.Pitting is not targeted to the oil glands.Less severe symptoms may show up as circular or arched areas of discoloration or scalding.Pac